Uji Efektivitas Analgesik Ekstrak Etanol Daun Sirih Hijau (Piper Betle Linn) Pada Hewan Mencit Putih Jantan

Atadjawa, Mardiana Kahi (2021) Uji Efektivitas Analgesik Ekstrak Etanol Daun Sirih Hijau (Piper Betle Linn) Pada Hewan Mencit Putih Jantan. Skripsi thesis, Universitas Kadiri.

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Abstract

Green betel leaf (Piper betle L) is a plant that has long been used by the community as an ingredient in traditional medicines, one of which is used to reduce pain (analgesic). This study aims to determine whether green betel leaf extract (Piper betle L.) has effectiveness as an analgesic against mice (Mus musculus) and to determine which treatment dose is the most effective in providing analgesic effects on mice (Mus musculus). This study used the hot plate method. This study used 25 male white mice with a body weight of 20-30 grams and mice 2-3 months old. This study used a completely randomized design (CRD) mice were divided into 5 groups, namely group I as a negative control was given CMC-Na, group II as a positive control was given aspirin, group III was a treatment group given green betel leaf extract (Piper betle L.) with a dose of 0.596 mg/kgBW mice, group IV is the treatment group given green betel leaf extract (Piper betle L.) with a dose of 1.192 mg/kgBW mice and group V is the treatment group given green betel leaf extract (Piper betle L.) with a dose of 2,348 mg/kgBW mice. The results of the data analysis test using SPSS with the Kruskal Wallis test obtained p-value < (0.05) while the test results using the Man Witney test obtained p-value < (0.05) so it can be concluded that there is a difference in the average analgesic effect in each study group. Based on the research results showed that the ethanol extract of green betel leaf (Piper betle L.) has analgesic activity and green betel leaf extract (Piper betle L.) at a dose of 2,348 mg is the most effective dose in providing analgesic effect on mice (Mus musculus). Keywords: Analgesic, Green Betel Leaf (Piper betle L.), Mice (Mus musculus)

Item Type:	Thesis (Skripsi)
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Fakultas Ilmu Kesehatan > Prodi Farmasi S1
Depositing User:	NR Nurul Huda
Date Deposited:	04 Nov 2021 02:28
Last Modified:	16 Nov 2021 01:16
URI:	http://repository.unik-kediri.ac.id/id/eprint/129

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